Nguyen, Phuhai published the artcileEvaluation of the antiprion activity of 6-aminophenanthridines and related heterocycles, COA of Formula: C5H5BrN2, the publication is European Journal of Medicinal Chemistry (2014), 363-371, database is CAplus and MEDLINE.
Several 6-(amino)phenanthridine derivatives and related heterocyclic compounds such as benzonaphtyridine derivatives were prepared A reduction of one of the three aromatic rings was also performed. The compounds were first tested for their antiprion activity in a previously described yeast-based colorimetric prion assay. The most potent derivatives were then assayed ex-vivo against the mammalian prion PrPSc in a cell-based assay. Several of the new compounds were found more potent than the parent lead 6-aminophenanthridine. The most promising compounds against yeast and mammalian prions were 8-azido-6-aminophenanthridine and 7,10-dihydrophenanthridin-6-amine. In the mammalian cell-based assay, the IC50 of these two compounds were around 5 μM and 1.8 μM, resp. The synthesis of the target compounds was achieved by a coupling reaction of boronic acid esters, such as 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenamine, 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile with suitable aryl bromides or aryl chlorides. The tilte compounds thus formed included 6-phenanthridinamine derivatives and analogs, such as benzo[c][2,6]naphthyridin-5-amine, benzo[h][1,6]naphthyridin-5-amine, benzo[c][1,8]naphthyridin-6-amine, benzo[c][1,6]naphthyridine, benzo[c]-1,5-naphthyridine.
European Journal of Medicinal Chemistry published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, COA of Formula: C5H5BrN2.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem