Ni, Ming Hong; Esposito, Emiliano; Castorina, Massimo; Dal Pozzo, Alma published an article in Letters in Drug Design & Discovery. The title of the article was 《Novel RGD peptidomimetics embedding 1,2,3-triazole as central scaffold; synthesis and αvβ3 integrin affinity》.HPLC of Formula: 1094679-27-2 The author mentioned the following in the article:
Ten new RGD (Arginine-Glycine-Aspartic acid) peptidomimetics have been synthesized and screened for their affinity to αvβ3 integrin receptor. Arginine and Aspartic acid mimetic subunits were connected through 1,2,3-triazole as central scaffold by click chem., affording the final products with good yields. Among them, compounds 3f-j exhibited high affinity to the receptor, with IC50 in the low nanomolar range, comparable to that of the reference compound Cilengitide. The experimental process involved the reaction of 4-Ethynylpyridin-2-amine(cas: 1094679-27-2HPLC of Formula: 1094679-27-2)
4-Ethynylpyridin-2-amine(cas: 1094679-27-2) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.HPLC of Formula: 1094679-27-2