On January 31, 1979, Nicholson, S. H.; Suckling, C. J.; Iversen, L. L. published an article.HPLC of Formula: 636-73-7 The title of the article was GABA analogs: conformational analysis of effects on [3H]GABA binding to postsynaptic receptors in human cerebellum. And the article contained the following:
A study of the inhibition of Na-independent 3H-labeled GABA [56-12-2] binding to synaptic membranes of human brain cortex by synthesized simple substituted GABA mols. and some related aromatic and heterocyclic amino acids showed that C-alkyl or -aryl substitution of the GABA mol. markedly reduced its ability to bind to the receptor. Rigid mols. were also unable to interact strongly with the receptor. The larger and more numerous the substituents, the weaker was the receptor binding of the GABA analog. For binding to the GABA receptor, the substituent blocked the approach of the charged atom of the ligand to its complementary site on the receptor, and also raised the energy of that conformation required for binding to the receptor. A planar, eclipsed, partially folded conformation must be adopted by GABA when it binds to its receptor. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).HPLC of Formula: 636-73-7
The Article related to gaba receptor structure activity, Pharmacodynamics: Structure-Activity and other aspects.HPLC of Formula: 636-73-7