Noori, Maryam; Shafaatian, Bita; Notash, Behrouz published the artcile< Synthesis of new platinum(IV) complexes through breaking disulfide bond; crystal structure determination, electrochemical, photoluminescence and DNA interaction investigation>, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane, the main research area is mercaptopyridinyl platinacycle preparation electrochem fluorescence DNA binding; crystal structure aryl mercaptopyridinyl platinacycle; mol structure aryl mercaptopyridinyl platinacycle.
New Pt(IV) complexes containing N2S2 donor atoms were synthesized by the reactions of [Pt(p-MeC6H4)2(SMe2)2] and [PtCl2(DMSO)2] with 2,2′-dithiopyridine (dtp) in 1:1 M ratio. In these reactions, 2-mercaptopyridine (mpy) ligands were formed through the cleavage of the disulfide bond in 2,2′-dithiopyridine. The mpy ligands were coordinated to the Pt center via the N and S atoms and the obtained Pt(IV) complexes exhibited octahedral geometry. The complexes were characterized by FTIR, 1H NMR, UV-visible, elemental analyses and conductometry. The crystal structure of the arylplatinum(IV) complex containing C2N2S2 donor atoms was determined by single crystal x-ray diffraction. The obtained molar conductance values revealed that the Pt(IV) complexes were nonelectrolytes. The interactions of the complexes with calf thymus DNA (CT-DNA) were studied by absorption and fluorescence spectroscopy, cyclic voltammetry and viscometry methods. The intrinsic binding constants (Kb) of the complexes with CT-DNA, obtained from UV-visible absorption data, were 9.60 × 104 M-1 and 11.56 × 104 M-1. Also, the enthalpy and entropy of the interaction between the Pt(IV) complexes and CT-DNA were calculated The obtained data revealed pos. enthalpy and entropy changes indicating a hydrophobic interaction between these complexes and CT-DNA.
Inorganica Chimica Acta published new progress about Bond cleavage (disulfide). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Recommanded Product: 1,2-Di(pyridin-2-yl)disulfane.