A comparative study of certain sulfisoxazole synthetic methods was written by Oeriu, S.;Voinescu, M.;Lupu, E.;Gloter, E.. And the article was included in Studii si Cercetari de Chimie in 1957.Synthetic Route of C12H8N4O This article mentions the following:
The 3 methods indicated (loc. cit.) for the synthesis of α-acetylpropionitrile, which on cyclization yielded dimethylaminoisoxazole were compared as were also the diverse variations for coupling the amine with p-acetamidobenzenesulfonyl chloride, and hydrolyzing the product. (11 references). In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Synthetic Route of C12H8N4O).
2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Synthetic Route of C12H8N4O