Recommanded Product: 29682-15-3In 2016 ,《Structure-activity relationship study of 4-(thiazol-5-yl)benzoic acid derivatives as potent protein kinase CK2 inhibitors》 was published in Bioorganic & Medicinal Chemistry. The article was written by Ohno, Hiroaki; Minamiguchi, Daiki; Nakamura, Shinya; Shu, Keito; Okazaki, Shiho; Honda, Maho; Misu, Ryosuke; Moriwaki, Hirotomo; Nakanishi, Shinsuke; Oishi, Shinya; Kinoshita, Takayoshi; Nakanishi, Isao; Fujii, Nobutaka. The article contains the following contents:
Two classes of modified analogs of 4-(thiazol-5-yl)benzoic acid-type CK2 inhibitors were designed. The azabenzene analogs, pyridine- and pyridazine-carboxylic acid derivatives, showed potent protein kinase CK2 inhibitory activities [IC50 (CK2α) = 0.014-0.017 μM; IC50 (CK2α’) = 0.0046-0.010 μM]. Introduction of a 2-halo- or 2-methoxy-benzyloxy group at the 3-position of the benzoic acid moiety maintained the potent CK2 inhibitory activities [IC50 (CK2α) = 0.014-0.016 μM; IC50 (CK2α’) = 0.0088-0.014 μM] and led to antiproliferative activities [CC50 (A549) = 1.5-3.3 μM] three to six times higher than those of the parent compound In addition to this study using Methyl 5-bromopicolinate, there are many other studies that have used Methyl 5-bromopicolinate(cas: 29682-15-3Recommanded Product: 29682-15-3) was used in this study.
Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridines, quinolines, and isoquinolines have found a function in almost all aspects of organic chemistry. Pyridine has found use as a solvent, base, ligand, functional group, and molecular scaffold. As structural elements, these moieties are potent electron-deficient groups, metal-directing functionalities, fluorophores, and medicinally important pharmacophores. Recommanded Product: 29682-15-3