Reactions of N-aminopyridinium derivatives. XII. Nucleophilic reactions of N-aminopyridinium derivatives was written by Ohsawa, Akio;Hirobe, Masaaki;Okamoto, Toshihiko. And the article was included in Yakugaku Zasshi in 1972.Recommanded Product: 1620-76-4 This article mentions the following:
Derivatives of N-aminopyridine were synthesized and these derivatives underwent reaction with nucleophilic reagents. Progress of this reaction depended on the activity of the reagents as a nucleophilic species, substituent effect of the substrate, and reaction conditions. Electron-withdrawing nature of the substituent on the amino group determines the activity of the substrate while that of the substituent on ring C determines the orientation of the reaction, the greater the electron-withdrawing nature of ring C the greater the orientation towards the 2-position. The reaction results in addition and (or) substitution reaction and the reaction can be explained without inconsistency by assuming the progress of this reaction in 2 steps of addition and liberation even when only a substitution product is obtained. Depending on whether the addition step is reversible or irreversible, each step will be controlled either by thermokinetics or by chem. kinetics, and orientation towards the 4- or 2-position will be determined by which of these forces would be stronger. In the experiment, the researchers used many compounds, for example, 4-Methylpicolinonitrile (cas: 1620-76-4Recommanded Product: 1620-76-4).
4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ闁荤姾娅ｅΛ纭俵闂? in pyridine vs. 150 kJ闁荤姾娅ｅΛ纭俵闂? in benzene). Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Recommanded Product: 1620-76-4