Application In Synthesis of 2-(2-Hydroxyethyl)pyridineIn 2019 ,《Highly Chemoselective gem-Difluoropropargylation of Aliphatic Alcohols》 appeared in Chemistry – A European Journal. The author of the article were Okamura, Toshitaka; Egoshi, Syusuke; Dodo, Kosuke; Sodeoka, Mikiko; Iwabuchi, Yoshiharu; Kanoh, Naoki. The article conveys some information:
α,α-Difluoropropargyl ethers were prepared by complexation of 3-bromo-3,3-difluoro-1-alkynes with dicobalt octacarbonyl, etherification with alcs. and decomplexation. Despite the potential of α-fluoroethers in medicinal chem., their synthetic methods, especially etherification of aliphatic alcs., have been limited. Herein, we developed two- and three-step gem-difluoropropargylation of aliphatic alcs. including amino acid derivatives and naturally occurring bioactive mols. Highly chemoselective etherification proceeded by using the gem-difluoropropargyl bromide dicobalt complex in the presence of silver triflate and triethylamine. Decomplexation of dicobalt complexes was achieved by using cerium ammonium nitrate or N,N,N’-trimethylethylenediamine. The thus obtained gem-difluoropropargyl ethers were converted to various α-difluoroethers which are expected to be useful for medicinal chem. In the experimental materials used by the author, we found 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Application In Synthesis of 2-(2-Hydroxyethyl)pyridine)
2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Application In Synthesis of 2-(2-Hydroxyethyl)pyridine