HPLC of Formula: 1122-54-9In 2022 ,《Synthesis, biological activities of chalcones and novel 4-acetylpyridine oximes, molecular docking of the synthesized products as acetylcholinesterase ligands》 appeared in Journal of Molecular Structure. The author of the article were Ould Lamara, Kamilia; Makhloufi-Chebli, Malika; Benazzouz-Touami, Amina; Terrachet-Bouaziz, Souhila; Robert, Anthony; Machado-Rodrigues, Carine; Behr, Jean-Bernard. The article conveys some information:
Heterocyclic chalcones I [X = O; R = C6H5, 4-MeOC6H4, 2-thienyl, etc.] were synthesized by reaction of 4-acetylpyridine with the corresponding aromatic aldehydes under Claisen Schmidt conditions. These chalcones I were used as starting material for the synthesis of oximes I [X = HON; R = 4-MeOC6H4, 4-ClC6H4, 2-thienyl, etc.] and II in the presence of hydroxylamine hydrochloride. The structures of the synthesized compounds I and II were confirmed by IR, 1H NMR, 13C NMR and ESI-MS, HRMS spectral analyses. All the synthesized compounds I and II were evaluated for their antioxidant activity by DPPH• method and their in-vitro antimicrobial activity by disk diffusion method against two Gram-neg. bacteria, one Gram-pos. bacteria and two fungal strains (C. albicans and A. niger). The results showed that the synthesized compounds I and II did not display significant antioxidant activity. However, I [X = O; R = 3-thienyl, C6H5, 4-O2NC6H4, 4-ClC6H4, 2,6-di-ClC6H3] showed excellent antibacterial activity better than the standard drug against the bacterial strain S. aureus (ATCC 25923). The two compounds I [X = O; R = (E)-styryl, C6H5] proved very active against the fungal strain A. niger (MIC= 7.81μg/ mL, 15.62μg/mL resp.) while the antifungal drug used as reference (Fluconazole) was inactive. Mol. docking and mol. dynamics results revealed that the synthesized compounds, I [X = HON; R = 4-MeOC6H4, (E)-styryl] and II were involved in a large number of favorable interactions with the active site residues of the acetylcholinesterase protein, which can stabilize the ligands in the active site and increase their affinities. In addition to this study using 4-Acetylpyridine, there are many other studies that have used 4-Acetylpyridine(cas: 1122-54-9HPLC of Formula: 1122-54-9) was used in this study.
4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.HPLC of Formula: 1122-54-9