Structure-activity relationships of novel non-competitive mGluR1 antagonists: A potential treatment for chronic pain was written by Owen, Dafydd R.;Dodd, Peter G.;Gayton, Simon;Greener, Ben S.;Harbottle, Gareth W.;Mantell, Simon J.;Maw, Graham N.;Osborne, Simon A.;Rees, Huw;Ringer, Tracy J.;Rodriguez-Lens, Margarita;Smith, Graham F.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2007.Product Details of 199296-39-4 This article mentions the following:
A series of novel mGluR1 antagonists have been prepared Incorporation of fragments derived from weak lead matter into a library led to enhanced potency in a new chem. series. A chem. driven second library iteration, covering a greatly enhanced area of chem. space, maintained good potency and introduced metabolic stability. Compound I may represent a useful lead in the ongoing search for mGluR1 antagonists for nociceptive pain. In the experiment, the researchers used many compounds, for example, 2-Methyl-2-(pyridin-2-yl)propan-1-amine (cas: 199296-39-4Product Details of 199296-39-4).
2-Methyl-2-(pyridin-2-yl)propan-1-amine (cas: 199296-39-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Product Details of 199296-39-4