Studies on phenylcyclopropanecarboxylates. 3. A convenient method for the preparation of 6-phenoxy-2-pyridinecarboxaldehyde was written by Ozawa, Kiyomi;Ishii, Shigeru;Hatanaka, Masataka. And the article was included in Chemistry Letters in 1985.Name: 2-Phenoxypyridine This article mentions the following:
Title aldehyde I (R = CHO) (II) was prepared in 62.4-93.6% yields from halides I (R = Br, Cl) via a Grignard reaction. Thus, the direct reaction of I (R = Br) with Mg in the presence or absence of EtBr or MeI in THF gave the corresponding Grignard reagent, which was treated with DMF to give II. II was obtained in 85.7% yield in the absence of EtBr or MeI, whereas the yields of II increased in the presence of EtBr. Grignard reactions had not been regarded as a good method for the synthesis of pyridinecarbaldehydes. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Name: 2-Phenoxypyridine).
2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Name: 2-Phenoxypyridine