Studies on 2,5-disubstituted-1,3,4-oxadiazoles. Part-I. Preparation and antimicrobial activity of 2-aryl-5-(4′-benzenesulfonamidophenyl)/(4′-pyridyl)-1,3,4-oxadiazoles was written by Pachhamia, V. L.;Parikh, A. R.. And the article was included in Journal of the Indian Chemical Society in 1989.Reference of 15420-02-7 This article mentions the following:
Fifty-two title compounds I and II (R = Ph, substituted Ph, cinnamyl, 4-hydroxycinnamyl, 3-pyridyl, 4-pyridyl) were prepared by cyclocondensation of 4-(PhSO2NH)C6H4CONHNH2 or isoniazide (III) with RCO2H in POCl3. Most of the compounds showed good activity against different strains of bacteria and fungi. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Reference of 15420-02-7).
2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Reference of 15420-02-7