Padivitage, Nilusha L.; Smuts, Jonathan P.; Breitbach, Zachary S.; Armstrong, Daniel W.; Berthod, Alain published an article in 2015, the title of the article was Preparation and Evaluation of HPLC Chiral Stationary Phases Based on Cationic/Basic Derivatives of Cyclofructan 6.Category: pyridine-derivatives And the article contains the following content:
The cyclofructan 6 (CF6) macrocyclic-oligosaccharide was derivatized with five different substituents able to bear pos. charges: Pr imidazole, Me benzimidazole, di-Me aminopropyl, pyridine, and di-Me aminophenyl. The derivatized cyclofructans were reacted with triethoxysilyl-propylisocyanate as a linker to bond them to 5μm spherical silica gel particles and then used to prepare liquid chromatog. columns. The bonded silica particles were analyzed to establish the bonding densities. A set of 34 chiral compounds including acids, neutral compounds, and bases was tested with nine different mobile phase compositions including two reverse phase (RP) acetonitrile/pH 4 buffer, three polar organic (PO) acetonitrile/methanol, and four normal phase (NP) heptane/ethanol mobile phases. No compounds could be separated in the RP mode. Eight compounds only could be enantiosepd. in the PO mode and 21 compounds in the NP mode. The most effective chiral stationary phase was the Pr imidazole derivatized CF6 phase, provided no more than six imidazole substituents and two linkers are attached per CF6 unit. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Category: pyridine-derivatives
The Article related to cyclofructan cationic derivative hplc chiral stationary phase enantiomer separation, liquid chromatography, cationic derivatives, chiral separation, cyclofructan, enantiomer separation and other aspects.Category: pyridine-derivatives