Pyridine-derivatives

Radial Control of Recognition and Redox Processes with Multivalent Nanoparticle Hosts was written by Boal, Andrew K.;Rotello, Vincent M.. And the article was included in Journal of the American Chemical Society in 2002.COA of Formula: C7H9N3O This article mentions the following:

Mixed monolayer protected gold clusters (MMPCs) featuring both hydrogen bonding and aromatic stacking mol. recognition functionalities have been used to create multivalent hosts for flavins. Multitopic binding of these hosts to flavin was shown to have a strong radial dependence: when the recognition site was brought closer to the MMPC surface, recognition was enhanced 闂?-fold due to increased preorganization. The effect of preorganization is reversed upon reduction of flavin, where the MMPC with longer side chains bind the flavin guest 闂?-fold stronger than the short chain counterpart due to unfavorable dipolar interactions between the electron-rich aromatic stacking units of the host and the anionic flavin guest. This fine-tuning of recognition and redox processes provides both a model for enzymic systems and a tool for the fabrication of devices. In the experiment, the researchers used many compounds, for example, N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3COA of Formula: C7H9N3O).

N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 闂?8.7 闂?10闂? cm3闁荤姾娅ｅΛ纭俵闂?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ闁荤姾娅ｅΛ纭俵闂? in the liquid phase and 140.4 kJ闁荤姾娅ｅΛ纭俵闂? in the gas phase. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.COA of Formula: C7H9N3O

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Investigating the Role of Ligand Electronics on Stabilizing Electrocatalytically Relevant Low-Valent Co(I) Intermediates was written by Hickey, David P.;Sandford, Christopher;Rhodes, Zayn;Gensch, Tobias;Fries, Lydia R.;Sigman, Matthew S.;Minteer, Shelley D.. And the article was included in Journal of the American Chemical Society in 2019.Product Details of 1257527-14-2 This article mentions the following:

Cobalt complexes have shown great promise as electrocatalysts in applications ranging from hydrogen evolution to C-H functionalization. However, the use of such complexes often requires polydentate, bulky ligands to stabilize the catalytically active Co(I) oxidation state from deleterious disproportionation reactions to enable the desired reactivity. Herein, we describe the use of bidentate electronically asym. ligands as an alternative approach to stabilizing transient Co(I) species. Using disproportionation rates of electrochem. generated Co(I) complexes as a model for stability, we measured the relative stability of complexes prepared with a series of N,N-bidentate ligands. While the stability of Co(I)Cl complexes demonstrates a correlation with exptl. measured thermodn. properties, consistent with an outer-sphere electron transfer process, the set of ligated Co(I)Br complexes evaluated was found to be preferentially stabilized by electronically asym. ligands, demonstrating an alternative disproportionation mechanism. These results allow a greater understanding of the fundamental processes involved in the disproportionation of organometallic complexes and have allowed the identification of cobalt complexes that show promise for the development of novel electrocatalytic reactions. In the experiment, the researchers used many compounds, for example, (S)-4-(tert-Butyl)-2-(4-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole (cas: 1257527-14-2Product Details of 1257527-14-2).

(S)-4-(tert-Butyl)-2-(4-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole (cas: 1257527-14-2) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 闂?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 闂?bonds. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Product Details of 1257527-14-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Catanionic mixtures of surface-active ionic liquids and N-lauroyl sarcosinate: Surface adsorption, aggregation behavior and microbial toxicity was written by Garcia, M. Teresa;Ribosa, Isabel;Gonzalez, Juan Jose;Comelles, Francesc. And the article was included in Journal of Molecular Liquids in 2020.Product Details of 104-73-4 This article mentions the following:

The surface activity and aggregation behavior of catanionic mixtures of imidazolium- or pyridinium-based surface-active ionic liquids (SAILs) and sodium N-lauroyl sarcosinate (Na-LS) in aqueous solution were investigated. The effects of the alkyl chain length, the polar head group and functional groups in the SAIL mol. on the interfacial properties and self-assembly of the catanionic mixtures were evaluated by surface tension and dynamic light scattering measurements. In addition, the toxicity of the catanionic surfactant mixtures against bacteria and fungi was studied. The SAIL-LS mixed systems reduced water surface tension with high effectiveness and efficiency, and had a lower critical aggregation concentration compared to the individual components. In all the catanionic systems investigated, synergistic effects caused by strong electrostatic and hydrophobic interactions resulted in neg. interaction parameter values, which increased with the alkyl chain length and in the order of non-functionalized < amide-functionalized < ester-functionalized SAILs. The structure of the mixed aggregates in the SAIL-LS catanionic systems depended on the hydrophobicity of the SAIL, the micelle-vesicle transition being driven by the alkyl chain length. The catanionic systems exhibited similar microbial toxicity to that of individual SAIL components and behaved like broad-spectrum antimicrobials. In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4Product Details of 104-73-4).

1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ闁荤姾娅ｅΛ纭俵闂? in pyridine vs. 150 kJ闁荤姾娅ｅΛ纭俵闂? in benzene). One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Product Details of 104-73-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Insights into the inhibition mechanism of 2,5-bis(4-pyridyl)-1,3,4-oxadiazole for carbon steel corrosion in hydrochloric acid pickling via experimental and computational approaches was written by Nadi, I.;Bouanis, M.;Benhiba, F.;Nohair, K.;Nyassi, A.;Zarrouk, A.;Jama, C.;Bentiss, F.. And the article was included in Journal of Molecular Liquids in 2021.Electric Literature of C12H8N4O This article mentions the following:

The addition of 2,5-bis(4-pyridyl)-1,3,4-oxadiazole (4-POX) as organic corrosion inhibitor of carbon steel (CS) in 1 M HCl solution was assessed exploiting weight loss and electrochem. measurements as well as surface anal. The gravimetric results showed that the 4-POX presents excellent anticorrosive properties on CS substrate, and its inhibition performance, 闂?(%), augmented with the 4-POX concentration to reach a maximum value of 93.6% at 1 mM afterwards 6 h embedding in 1 M HCl at 303 K. The AC impedance findings revealed that the addition of 4-POX to the corrosive medium leads to a decrease of the charge capacitance resulting in a systematic improve of the interface charge/discharge function and forms an adsorbed layer over the metal surface. Furthermore, SEM, water contact angle and XPS methods supported the development of a protective film over CS substrate surface afterwards addition of 4-POX. DFT calculations and MD simulations of 2,5-bis(n-pyridyl)-1,3,4 oxadiazole (n = 2, 3 and 4) derivatives were exploited to get better insight, about structural and electronic effects in relation to the anticorrosion properties and to envisage the interactions of the investigated inhibitors with metal surface atoms along with corrosive species. The cytotoxicity of 4-POX was also determined using the cell culture system. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Electric Literature of C12H8N4O).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Electric Literature of C12H8N4O

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Facile preparation of thiophene C2-ethers using the Mitsunobu reaction was written by Harris, Craig S.;Germain, Herve;Pasquet, Georges. And the article was included in Tetrahedron Letters in 2008.Formula: C12H18N2O2 This article mentions the following:

The preparation of thiophene ethers generally requires forcing conditions thus limiting the choice of alkyl substituent. Herein, we report the first successful generally applicable conditions for the selective O-alkylation of 2(5H)-thiophenone. In the experiment, the researchers used many compounds, for example, tert-Butyl methyl(6-methylpyridin-2-yl)carbamate (cas: 205676-84-2Formula: C12H18N2O2).

tert-Butyl methyl(6-methylpyridin-2-yl)carbamate (cas: 205676-84-2) belongs to pyridine derivatives. Pyridine has a conjugated system of six 闂?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H闂佹椿浜滈妴鍗l criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Formula: C12H18N2O2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

[Cp*Rh^III]/Ionic Liquid as a Highly Efficient and Recyclable Catalytic Medium for C-H Amidation was written by Ma, Qiang;Yu, Xinling;Lai, Ruizhi;Lv, Songyang;Dai, Weiyang;Zhang, Chen;Wang, Xiaolong;Wang, Qiantao;Wu, Yong. And the article was included in ChemSusChem in 2018.SDS of cas: 4373-61-9 This article mentions the following:

The first general procedure for direct C-H amidation under ambient reaction conditions with [Cp*Rh^III]/[BMIM]BF₄ as a highly efficient and sustainable catalyst system was developed. Various kinds of DG-containing substrates, including synthetically useful N-containing heterocycles, amides, ketoximes, and N-oxides were selectively amidated with high regio- and stereoselectivity and excellent functional-group compatibility. This strategy allowed direct amidation of both C(sp²)-H and inert C(sp³)-H bonds to yield monoamidation products, e.g., I and quinolines II [R = H, 5-Me, 5-NO₂, etc.] without addnl. heating and in shorter reaction times than in organic solvents. A range of quinolone precursors could be easily synthesized by this method. Most importantly, this system is very easy to handle and could be recycled and reused for at least four runs without showing significant loss of activity. This facile and environmental friendly protocol could be increase the applicability of ionic liquids in C-H bond activation. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9SDS of cas: 4373-61-9).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ闁荤姾娅ｅΛ纭俵闂? in pyridine vs. 150 kJ闁荤姾娅ｅΛ纭俵闂? in benzene). One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.SDS of cas: 4373-61-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Effect of anion and alkyl chain length on the structure and interactions of N-alkyl pyridinium ionic liquids was written by Potangale, Mangesh;Das, Abhishek;Kapoor, Sudhir;Tiwari, Shraeddha. And the article was included in Journal of Molecular Liquids in 2017.SDS of cas: 104-73-4 This article mentions the following:

The structure and interactions of a series of ionic liquids composed of N-alkyl pyridinium cation ([C_nPy]⁺, n = 2, 4, 6, 8, 10, 12, 14) with varied anions like bromide (Br^–), tetrafluoroborate ([BF₄]^–), bis(trifluoromethanolsulfonyl)imide ([NTf₂]^–) and hexafluorophosphate ([PF₆]^–) were investigated using ATR – FTIR and Raman spectroscopy. The observed frequencies were compared to the frequencies computed by means of DFT theory at the B3LYP/6-311++G(d,p) level. Significant variations were observed in the vibrational spectra of the pyridinium based ionic liquids, with increasing chain length of the alkyl group in the cation. The nature and extent of the chain-length dependent variations in the spectra was also dependent on the anionic species present in the sample. Comparison of the observed spectra to the computed spectra and previously reported data for imidazolium based ionic liquids indicated mesoscopic segregation of polar and nonpolar regions in the pyridinium ionic liquids The strength of the cation-anion interaction determines the nature and extent of such microscopic heterogeneity, which was reflected in the anion-specific variations in the vibrational spectra. While the mesoscopic reorganization of pyridinium based ionic liquids was analogous to that in imidazolium based ionic liquids, some important differences were also noted. The observations highlighted the importance of all three structural features – cation, anion and alkyl chain length – in determining the microscopic organization and properties of ionic liquids The results emphasized the need for broadening the scope of ionic liquid research to include more studies on the non-imidazolium based ionic liquids In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4SDS of cas: 104-73-4).

1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.SDS of cas: 104-73-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis and biological evaluation of some pyridine derivatives as antimicrobial agents was written by Ali Hussen, Dagim;Bekhit, Adnan A.;Hymete, Ariaya. And the article was included in Ethiopian Pharmaceutical Journal in 2009.Formula: C12H8N4O This article mentions the following:

In this study, several pyridine derivatives were prepared and evaluated for their in-vitro antimicrobial activity against Gram-pos. bacteria (Bacillus cereus and Staphylococcus aureus), Gram-neg. bacteria (Escherichia coli and Pseudomonas aeruginosa) and fungi (Aspergillus niger and Candida albicans). The synthesis of the target compounds was achieved using 1-phenylethanone and 1-(4-chlorophenyl)-3-phenyl-1H-pyrazole-4-carboxaldehyde and 1-(4-methylphenyl)-3-phenyl-1H-pyrazole-4-carboxaldehyde as starting materials and a second series was obtained using 4-pyridinecarboxaldehyde and amines or hydrazides as starting materials. The products thus obtained [i.e., 1,2-dihydro-4-[1-(aryl)-3-phenyl-1H-pyrazol-4-yl]-2-oxo-6-phenyl-3-pyridinecarbonitrile derivatives and Schiff base imines and hydrazides] were confirmed by IR, ¹H-NMR, ¹³C-NMR and elemental anal. An evaluation of the toxicity profile revealed that oral and parenteral LD₅₀s are more than 300 mg/kg and 100 mg/kg, resp., and it was discovered that the title compounds displayed antimicrobial activity. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Formula: C12H8N4O).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Formula: C12H8N4O

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

C-H Silylation of 2-Arylpyridine Derivatives by Using Iridium Catalyst and Phosphine-Borane Ligand was written by Anoyama, Keita;Onodera, Gen;Fukuda, Tsutomu;Kimura, Masanari. And the article was included in Advanced Synthesis & Catalysis in 2022.HPLC of Formula: 4373-61-9 This article mentions the following:

Iridium-catalyzed ortho-C-H silylation of 2-arylpyridine derivative with hydrosilane by using phosphine-borane ligands has been developed. A variety of 2-arylpyridines could be used for this reaction to give mono- and disilylated products in 81-99% yields. In this reaction, the length of linkage between phosphorus and boron plays an important role for the reaction to proceed. We consider that the nitrogen in 2-arylpyridine coordinates to Lewis acidic boron in the ligand and thus the iridium is led to an ortho-C-H bond to cleave it. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9HPLC of Formula: 4373-61-9).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. HPLC of Formula: 4373-61-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Molecular Engineering and Design of Semiconducting Polymer Dots with Narrow-Band, Near-Infrared Emission for in Vivo Biological Imaging was written by Ke, Chi-Shiang;Fang, Chia-Chia;Yan, Jia-Ying;Tseng, Po-Jung;Pyle, Joseph R.;Chen, Chuan-Pin;Lin, Shu-Yi;Chen, Jixin;Zhang, Xuanjun;Chan, Yang-Hsiang. And the article was included in ACS Nano in 2017.Synthetic Route of C5H6ClN This article mentions the following:

This article describes the design and synthesis of donor-bridge-acceptor-based semiconducting polymer dots (Pdots) that exhibit narrow-band emissions, ultrahigh brightness, and large Stokes shifts in the near-IR (NIR) region. The authors systematically studied the effect of 闂?bridges on the fluorescence quantum yields of the donor-bridge-acceptor-based Pdots. The Pdots could be excited by a 488 or 532 nm laser and have a high fluorescence quantum yield of 33% with a Stokes shift of >200 nm. The emission full width at half-maximum of the Pdots can be as narrow as 29 nm, 闂?.5 times narrower than that of inorganic quantum dots at the same emission wavelength region. The average per-particle brightness of the Pdots is at least 3 times larger than that of the com. available quantum dots. The excellent biocompatibility of these Pdots was demonstrated in vivo, and their specific cellular labeling capability was also approved by different cell lines. By taking advantage of the durable brightness and remarkable stability of these NIR fluorescent Pdots, the authors performed in vivo microangiog. imaging on living zebrafish embryos and long-term tumor monitoring on mice. The authors anticipate these donor-bridge-acceptor-based NIR-fluorescent Pdots with narrow-band emissions to find broad use in a variety of multiplexed biol. applications. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Synthetic Route of C5H6ClN).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C闂備胶鍋ㄩ崕鎻掝嚕?in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Synthetic Route of C5H6ClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem