Recommanded Product: 2-BromonicotinaldehydeIn 2018 ,《Synthesis of Pyrimidine Fused Quinolines by Ligand-Free Copper-Catalyzed Domino Reactions》 appeared in Journal of Organic Chemistry. The author of the article were Panday, Anoop Kumar; Mishra, Richa; Jana, Asim; Parvin, Tasneem; Choudhury, Lokman H.. The article conveys some information:
Herein we report two novel methods for the synthesis of pyrimidine fused quinolines using one-pot C-C and C-N bond forming strategy from the reaction of 6-amino uracils with 2-bromo benzaldehydes or 2-bromobenzyl bromide derivatives in the presence of 10-mol% CuCl2 without using any ligand. The reaction of 2-bromobenzaldehyde or its derivatives with 6-amino-uracils in the presence K2CO3 as base and catalytic amount of CuCl2 in DMF medium under microwave heating conditions provide corresponding pyrimidine-fused quinoline derivatives in good yields within 30 min. Alternatively, pyrimidine fused quinoline derivatives have been synthesized from the reaction of 2-bromobenzyl bromides with 6-amino-uracil derivatives in the presence of mol. oxygen, CuCl2 (10-mol%) and K2CO3 as base in DMF under reflux conditions. Structures of all the products were unambiguously confirmed by spectroscopic techniques and by recording single crystal XRD of I. In addition to this study using 2-Bromonicotinaldehyde, there are many other studies that have used 2-Bromonicotinaldehyde(cas: 128071-75-0Recommanded Product: 2-Bromonicotinaldehyde) was used in this study.
2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Recommanded Product: 2-Bromonicotinaldehyde