Pandopulos, Aaron J.; Gerber, Cobus; Tscharke, Benjamin J.; O’Brien, Jake; White, Jason M.; Bade, Richard published the artcile< A sensitive analytical method for the measurement of neurotransmitter metabolites as potential population biomarkers in wastewater>, Application of C10H8N2S2, the main research area is neurotransmitter metabolite determination wastewater analysis; liquid chromatog tandem mass spectrometry neurotransmitter metabolite determination wastewater; population biomarker wastewater epidemiol neurotransmitter metabolite determination; hydroxyindoleacetic acid vanillylmandelic acid homovanillic acid neurotransmitter metabolite biomarker; 5-hydroxyindoleacetic acid; Homovanillic acid; Mass spectrometry; Population biomarker; Vanillylmandelic acid; Wastewater-based epidemiology.
Wastewater-based epidemiol. is a growing research field which provides valuable information on community drug use and chem. exposure. One parameter critical to estimate drug use is catchment area population. A population biomarker could provide this information. This work evaluated the anal. suitability of three human activity endogenous biomarkers: the previously proposed serotonin metabolite, 5-hydroxyindoleacetic acid (5-HIAA); and two other candidates, the catecholamine metabolites, vanillylmandelic acid (VMA) and homovanillic acid (HVA). A derivatization-involved anal. method was developed and validated for 5-HIAA and HVA: liquid chromatog./mass spectrometry. Best performance was obtained for VMA as an underivatized analyte. Derivatized extracts produced 100 times better sensitivity. The three neurotransmitter metabolites were evaluated as population biomarkers in wastewater. All were stable, not lost upon filtration, and displayed stable inter-day mass loads over seven days for a metropolitan wastewater treatment facility. When used for a small community during a festival, mass HVA and VMA loads reflected an increase in catchment population; 5-HIAA was more variable.
Journal of Chromatography A published new progress about Biomarkers (endogenous human activity neurotransmitter metabolite). 2127-03-9 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2S2, Application of C10H8N2S2.