Pang, Maofu; Shi, Le-Le; Xie, Yufang; Geng, Tianyi; Liu, Lan; Liao, Rong-Zhen; Tung, Chen-Ho; Wang, Wenguang published the artcile< Cobalt-Catalyzed Selective Dearomatization of Pyridines to N-H 1,4-Dihydropyridines>, Computed Properties of 93-60-7, the main research area is pyridine cobalt catalyst chemoselective regioselective dearomatization; dihydropyridine preparation.
Catalytic reduction of pyridines to N-H 1,4-dihydropyridines was exceptionally challenging because they are essential intermediates to form tetrahydropyridines. Using a facile dihydrogen source H3N·BH3 to activate the pyridine ring in situ, was achieved by selective transfer hydrogenation of nicotinate derivatives to N-H 1,4-dihydropyridines by cobalt-amido cooperative catalysis. The reactions operated smoothly under mild conditions to produce a variety of N-H 1,4-dihydropyridines with high chemo- and regioselectivity. This catalytic method also provides a practical protocol to regenerate Hantzsch analogs after delivery of H2.
ACS Catalysis published new progress about Chemoselectivity. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Computed Properties of 93-60-7.