Pang, Yuan-Ping published the artcileSmall molecules showing significant protection of mice against botulinum neurotoxin serotype A, COA of Formula: C6H5F4NO3S, the publication is PLoS One (2010), 5(4), No pp. given, database is CAplus and MEDLINE.
Botulinum neurotoxin serotype A (BoNTA) causes a life-threatening neuroparalytic disease known as botulism that could afflict large, unprotected populations if the toxin were employed in an act of bioterrorism. Current post-exposure therapy is limited to symptomatic treatment or passive immunization that is effective for treating infant botulism at a cost of US $45,300 per treatment regimen. Antibodies can neutralize the extracellular but not the intracellular BoNTA. Moreover, antibody production, storage, and administration in a mass casualty scenario pose logistical challenges. Alternatively, small-mol. inhibitors of BoNTA endopeptidase (BoNTAe) are sought to antagonize the extracellular or intracellular toxin. While several such mols. reportedly demonstrated efficacy in protecting cells against BoNTA, there is scant information to show that small mols. can significantly protect mammals against BoNTA. Herein the authors report the development of effective small-mols. BoNTAe inhibitors with promising in vivo pharmacokinetics. One such mol. has an in vivo half-life of 6.5 h and is devoid of obvious sign of toxicity. Pre-treatment with this mol. at 2 mg/kg protected 100% and 70% of treated mice against BoNTA at 5 times of its median-LD during the periods of 2 and 4 half-lives of the inhibitor, resp. In contrast, 40% and 0% of untreated mice survived during the resp. periods. Similar levels of protection were also observed with two other small mols. These results demonstrate that small mols. can significantly protect mice against BoNTA and support the pursuit of small-mol. antagonists as a cost-effective alternative or as an adjunct to passive immunity for treating botulism.
PLoS One published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C6H5F4NO3S, COA of Formula: C6H5F4NO3S.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem