Related Products of 98-98-6In 2021 ,《Molecular docking, DFT and antimicrobial studies of Cu(II) complex as topoisomerase I inhibitor》 was published in Journal of Biomolecular Structure and Dynamics. The article was written by Parveen, Shazia; Arjmand, Farukh; Zhang, Qianfan; Ahmad, Musheer; Khan, Arif; Toupet, Loic. The article contains the following contents:
Herein, we report the synthesis and single crystal X-ray structure of Cu(II)-picolinic acid complex, as a potent topoisomerase I inhibitor. The complex crystallized in the triclinic crystal system with space group P-1. Comparative in vitro binding studies of complex with CT DNA and tRNA were carried out revealing an electrostatic binding mode with higher binding propensity towards tRNA. The intrinsic bonding constant value, Kb was calculated to be 4.36 x 104 and 8.78 x 104 M-1 with CT DNA and tRNA resp. DNA cleavage activity was carried out with a pBR322 plasmid DNA substrate to ascertain the cleaving ability. Furthermore, Topo-I inhibition assay of complex , performed via gel electrophoresis revealed a significant inhibitory effect on the enzyme catalytic activity at a min. concentration of 15 muM. The DFT studies were carried out to provide better insight in the electronic transitions observed in the absorption spectrum of the complex . Mol. docking studies were carried out with DNA, RNA and Topo-I to determine the specific binding preferences at the target site and complement the spectroscopic studies. The antimicrobial potential of complex was screened against E. coli, S. aureus, P. aeruginosa, B. subtilis and C. albicans; and compared with doxycycline, exhibiting an excellent maximum zone of inhibition of 28 mm against E. coli. The results came from multiple reactions, including the reaction of Picolinic acid(cas: 98-98-6Related Products of 98-98-6)
Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Related Products of 98-98-6