Quaternization at the picolinic carbon. Application to the synthesis of pyridylalkanecarboxylic acids was written by Pasquinet, Eric;Rocca, Patrick;Godard, Alain;Marsais, Francis;Queguiner, Guy. And the article was included in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry in 1998.COA of Formula: C8H11N This article mentions the following:
This paper describes two different methodologies for the construction of a quaternary center at the picolinic site, and their application to the synthesis of pyridylalkanecarboxylic acids. The first one involves a one-pot acetylation-Michael addition procedure followed by an alkylative quaternization of the picolinic carbon. The second one is based on the deprotonation at the picolinic carbon of 2-(浼?浼?dialkyl)pyridines using the superbasic mixture BuLi-diisopropylamine-tert-BuOK (“KDA”). Both routes give very good yields. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4COA of Formula: C8H11N).
2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. COA of Formula: C8H11N