Paul, Lindsey; Enkhbold, Khuslen; Robinson, Sydney; Aye, Than Thar; Chung, Yuna; Harrison, Daniel P.; Pollock, Julie A.; Norris, Michael R. published the artcile< Unravelling the role of [Ru(bpy)2(OH2)2]2+ complexes in photo-activated chemotherapy>, COA of Formula: C10H8N2, the main research area is Breast cancer; Cytotoxicity; Lung cancer; Photoactivation; Polypyridyl; Ruthenium.
Photoactivated chemotherapy (PACT) has emerged as a promising strategy to selectively target cancer cells by using light irradiation to generate cytotoxic complexes in situ through a mechanism involving ligand-loss. Due to their rich optical properties and excited state chem., Ru polypyridyl complexes have attracted significant attention for PACT. However, studying PACT is complicated by the fact that many of these Ru complexes can also undergo excited-state electron transfer to generate 1O2 species. In order to deconvolute the biol. roles of possible photo-decomposition products without the added complication of excited-state electron transfer chem., we have developed a methodol. to systematically investigate each product individually, and assess the structure-function relationship. Here, we synthesized a series of eight distinct Ru polypyridyl complexes: Ru-Xa ([Ru(NN)3]2+), Ru-Xb ([Ru(NN)2py2]2+), and Ru-Xc ([Ru(NN)(OH2)2]2+) where NN = 2,2′-bipyridine, 4,4′-dimethyl-2,2′-bipyridine, or di-Me 2,2′-bipyridine-4,4′-dicarboxylate and py = pyridine. The cytotoxicity of these complexes was investigated in two cell lines amenable to PACT: H23 (breast cancer) and T47D (lung cancer). We confirmed that light irradiation of Ru-Xa and Ru-Xb complexes generate Ru-Xc complexes through UV-visible spectroscopy, and observed that the Ru-Xc complexes are the most toxic against the cancer cell lines. In addition, we have shown that ligand release and biol. activity including bovine serum albumin (BSA) binding, lipophilicity, and DNA interaction are altered when different groups are appended to the bipyridine ligands. We believe that the methodol. presented here will enhance the development of more potent and selective PACT agents moving forward.
Journal of Inorganic Biochemistry published new progress about 366-18-7. 366-18-7 belongs to class pyridine-derivatives, and the molecular formula is C10H8N2, COA of Formula: C10H8N2.