Pavia, Michael R. published the artcileN,N-Disubstituted 6-alkoxy-2-pyridinamines as anticonvulsant agents, HPLC of Formula: 42144-78-5, the main research area is alkoxypyridinamine preparation anticonvulsant; chloropyridine alkoxylation; alkoxychloropyridine aminolysis piperazine piperidine morpholine; pyridinamine alkoxy preparation anticonvulsant; aminopyridine alkoxy preparation anticonvulsant.
The anticonvulsant effect of a series of title compounds I (R = Me, Et, Me2CH, Me2CHCH2, Me2NCH2CH2, cyclopropylmethyl, cyclohexyl, cyclohexylmethyl; R1 = e.g., piperazino, piperidino, morpholino) is described. The activity/side-effect ratio in this series of compounds was optimized. I (R = Me2CHCH2; R1 = piperazino) (II) showed the most desirable profile, and was selected for a more complete pharmacol. evaluation. Overall, the pharmacol. profile of II is very similar to that of diphenylhydantoin (phenytoin). While II is nearly equipotent to phenytoin, animal studies suggest a fairly short duration of action. In addition, II exhibited some troublesome side effects including central nervous system depression and hypothermia.
Journal of Medicinal Chemistry published new progress about Alkoxylation. 42144-78-5 belongs to class pyridine-derivatives, name is 2-Chloro-6-ethoxypyridine, and the molecular formula is C7H8ClNO, HPLC of Formula: 42144-78-5.