Pavia, Michael R. published the artcileN-Phenyl-N’-pyridinylureas as anticonvulsant agents, Recommanded Product: 4-Amino-2-picoline, the publication is Journal of Medicinal Chemistry (1990), 33(2), 854-61, database is CAplus and MEDLINE.
A series of N-phenyl-N‘-pyridinylureas, e.g., I (R, R1, R2, R3 = H, Cl, Br, F, CF3, Me, Et, CHMe2, NO2, NH2, OMe, etc.) was prepared by the reaction of aryl isocyanates with 2-, 3-, of 4-aminopyridine. They were examined for anticonvulsant activity. Extensive structure/activity investigations revealed optimal activity in the N-(2,6-disubstituted-phenyl)-N‘-(4-pyridinyl)urea series, with I (R = Cl, R1 = R2 = H, R3 = Me) (II) exhibiting the best overall anticonvulsant profile. II was effective against seizures induced by maximal electroshock but did not protect mice from clonic seizures produced by the convulsant pentylenetetrazol. The overall pharmacol. profile suggests that II would be of therapeutic use in the treatment of generalized tonic-clonic and partial seizures. II was selected for Phase 1 clin. trials.
Journal of Medicinal Chemistry published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Recommanded Product: 4-Amino-2-picoline.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem