Paymode, Dinesh J.; Chang, Le; Chen, Dan; Wang, Binglin; Kashinath, Komirishetty; Gopalsamuthiram, Vijayagopal; McQuade, D. Tyler; Vasudevan, N.; Ahmad, Saeed; Snead, David R. published their research in Organic Letters in 2021. The article was titled 《Application of Vinamidinium Salt Chemistry for a Palladium Free Synthesis of Anti-Malarial MMV048: A “”Bottom-Up”” Approach》.Product Details of 624-28-2 The article contains the following contents:
MMV390048 is a clin. compound under investigation for antimalarial activity. A new synthetic route was developed which couples two aromatic fragments while forming the central pyridine ring over two steps. This sequence takes advantage of raw materials used in the existing etoricoxib supply chain and eliminates the need for palladium catalysts, which were projected to be major cost-drivers. In the experimental materials used by the author, we found 2,5-Dibromopyridine(cas: 624-28-2Product Details of 624-28-2)
2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Product Details of 624-28-2