Fluorinated Aminopyridines: Synthesis, Structure, and Rare Liquid-Liquid Cocrystal Formation Driven by Unusually Short N-H路路路F-C Hydrogen Bonding was written by Peloquin, Andrew J.;Kure, Daniel A.;Jennings, Abby R.;McMillen, Colin D.;Iacono, Scott T.;Pennington, William T.. And the article was included in Crystal Growth & Design in 2020.Category: pyridine-derivatives The following contents are mentioned in the article:
Perfluoropyridine underwent nucleophilic aromatic substitution with excesses of unhindered primary and secondary amines to yield tetrafluoro-4-pyridinamines. The structures for twelve of the products were determined by X-ray crystallog. Perfluoropyridine formed solid cocrystals with dicyclohexylamine and 2-methylpiperidine; the complexes were stable to approx. 100掳C above the normal b.p. of perfluoropyridine. The solid state packing in the cocrystals of perfluoropyridine with dicyclohexylamine and 2-methylpiperidine was dominated by hydrogen bonding between pyridine C-F bonds and the amine N-H bonds. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Category: pyridine-derivatives).
2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJè·¯molé? in pyridine vs. 150 kJè·¯molé? in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Category: pyridine-derivatives