Taxonomic significance and antitumor activity of alkaloids from Clausena lansium Lour. Skeels (Rutaceae) was written by Peng, Wen-Wen;Fu, Xiao-Xiang;Xiong, Zhong-Hua;Wu, Hong-Liang;Chang, Jing-Wen;Huo, Guang-Hua;Li, Bao-Tong. And the article was included in Biochemical Systematics and Ecology in 2020.Name: Pyridin-4-ol This article mentions the following:
Phytochem. anal. of isolates from the aerial parts of Clausena lansium Lour. Skeels (Rutaceae) led to the identification of 14 alkaloids, including two indole alkaloids (1 and 2), one quinoline alkaloid (3), two pyridine alkaloids (4 and 5), four carbazole alkaloids (6-9) and five amides alkaloids (10-14). The phytochem. structures of the alkaloids were established by means of NMR and MS spectral analyses. Compounds (4, 5, 14) were three new natural products, while 1-3 and 10 were firstly reported from the genus Clausena and 8 and 9 were isolated from this species for the first time. The chemotaxonomic significance of these isolated alkaloids has also been discussed. All the isolated alkaloids were tested for their cytotoxic activity against Hela cancer cell line. Among them, four carbazole alkaloids 6-9 exhibited weak cytotoxicity with IC50 values ranging from 69.31 to 138.32μM. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Name: Pyridin-4-ol).
Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Name: Pyridin-4-ol