TBHP promoted demethylation of α-amino carbonyl compounds: a concise approach to substituted γ-lactams was written by Peng, Xue;Wang, Hui-Hong;Cao, Fei;Zhang, Hong-Hua;Lu, Ying-Mei;Hu, Xiao-Ling;Tan, Wen;Wang, Zhen. And the article was included in Organic Chemistry Frontiers in 2019.Quality Control of tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate This article mentions the following:
A novel tert-Bu hydroperoxide (TBHP) promoted CH2-extrusion reaction of α-amino carbonyl compounds I (R = Me, naphthalen-2-ylmethyl, Bn, cyclopropyl, etc.; R1 = H, Me, Et, Br; R2 = H, (CH3)2; R3 = H, Me; R1R3 = -CH=CH-CH=CH-; A = (CHR3)1-2; R4 = H, Me, allyl, Bn) has been developed, which is driven by a demethylenation process to give various ring contraction products γ-lactams II under radical conditions. The reaction shows good functional group tolerance and excellent chemo/regioselectivity; all the desired products are obtained in moderate to excellent yields. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Quality Control of tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate).
tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Quality Control of tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate