Product Details of 53939-30-3In 2014 ,《Continuous flow magnesiation of functionalized heterocycles and acrylates with TMPMgCl.LiCl》 appeared in Angewandte Chemie, International Edition. The author of the article were Petersen, Trine P.; Becker, Matthias R.; Knochel, Paul. The article conveys some information:
The metalation of functionalized heterocycles (pyridines, pyrimidines, thiophenes, and thiazoles) and various acrylates using the strong, non-nucleophilic base TMPMgCl.LiCl was carried out. The flow conditions allow the magnesiations to be performed under more convenient conditions than the comparable batch reactions, which often require cryogenic temperatures and long reaction times. Moreover, the flow reactions are directly scalable without further optimization. Metalation under flow conditions also allows magnesiations that did not produce the desired products under batch conditions, such as the magnesiation of sensitive acrylic derivatives The magnesiated species are subsequently quenched with various electrophiles, thereby introducing a broad range of functionalities. © 2014 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim. The results came from multiple reactions, including the reaction of 5-Bromo-2-chloropyridine(cas: 53939-30-3Product Details of 53939-30-3)
5-Bromo-2-chloropyridine(cas: 53939-30-3) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Product Details of 53939-30-3