Piao, Ming-Zhu; Imafuku, Kimiaki published the artcile< Friedlaender reaction of 3-acetyltropolones: synthesis of naphthyridinyl- and allied heterocyclic-substituted tropolones>, Application of C6H6N2O, the main research area is acetyltropolone Friedlaender reaction aminopyridinecarboxaldehyde; naphthyridinyl tropolone preparation; pyridopyrazinyl tropolone preparation; tropolone naphthyridinyl pyridopyrazinyl pyrazolopyridinyl preparation; pyrazolopyridinyl tropolone preparation.
The reaction of 3-acetyltropolones I (R1 = H, Me, Br, etc.; R2 = H, Br) with 2-amino-3-pyridinecarbaldehyde gave 3-(1,8-naphthyridin-2-yl)tropolones II (same R1, R2) in excellent yields. In a similar manner, 1,6-naphthyridin-2-yl, 1,7-naphthyridin-2-yl-, 6-pyrido[2,3-b]pyrazinyl-, and 1-methyl-6-pyrazolo[5,4-b]pyridyl-substituted tropolones were prepared Reactivities of amino-substituted heteroarenecarbaldehydes in these reactions and properties of the products were also discussed.
Journal of Heterocyclic Chemistry published new progress about Friedlander synthesis. 55279-29-3 belongs to class pyridine-derivatives, and the molecular formula is C6H6N2O, Application of C6H6N2O.