Pickart, Loren published the artcileInhibition of the growth of cultured cells and an implanted fibrosarcoma by aroylhydrazone analogs of the Gly-His-Lys-copper(II) complex, Category: pyridine-derivatives, the publication is Biochemical Pharmacology (1983), 32(24), 3868-71, database is CAplus and MEDLINE.
Both salicylaldehydebenzoylhydrazonato-Cu(II) chloride hydrate (I) [83614-45-3] and pyridine-2-carboxaldehyde-2-pyridylhydrazonato-Cu(II) dichloride (II) [46847-77-2] inhibited DNA formation in 6 types of human and mouse cultured cells (normal and neoplastic). The degree of inhibition by I or II was comparable to that obtained with cisplatin, bleomycin, and thiotepa. In vivo, I or II injection into the tumor area of mice implanted s.c. with MCA1511 fibrosarcoma resulted in marked tumor-size regression. I.p. treatment of the transplanted tumors was less effective in controlling tumor growth. The Cu-free ligands were inactive as antitumor agents. Thus, I and II, both analogs of Gly-His-Lys-Cu(II), are potent antimitotic and antineoplastic agents.
Biochemical Pharmacology published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Category: pyridine-derivatives.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem