The author of 《Rapid Asymmetric Synthesis of Disubstituted Allenes by Coupling of Flow-Generated Diazo Compounds and Propargylated Amines》 were Poh, Jian-Siang; Makai, Szabolcs; von Keutz, Timo; Tran, Duc N.; Battilocchio, Claudio; Pasau, Patrick; Ley, Steven V.. And the article was published in Angewandte Chemie, International Edition in 2017. Recommanded Product: 2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine The author mentioned the following in the article:
The authors report the asym. coupling of flow-generated unstabilized diazo compounds and propargylated amide derivatives, using a new pyridinebis(imidazoline) ligand, a copper catalyst, and base. The reaction proceeds rapidly, generating chiral allenes in 10-20 min with high enantioselectivity (89-98 % de/ee), moderate yields and a wide functional group tolerance. In the experiment, the researchers used many compounds, for example, 2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 410092-98-7Recommanded Product: 2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine)
2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine(cas: 410092-98-7) belongs to pyridine derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals. Recommanded Product: 2,6-Bis((4S,5S)-4,5-diphenyl-4,5-dihydrooxazol-2-yl)pyridine