The author of 《Iron-Catalyzed Borrowing Hydrogen β-C(sp3)-Methylation of Alcohols》 were Polidano, Kurt; Williams, Jonathan M. J.; Morrill, Louis C.. And the article was published in ACS Catalysis in 2019. Application In Synthesis of 2-(2-Hydroxyethyl)pyridine The author mentioned the following in the article:
Herein we report the iron-catalyzed β-C(sp3)-methylation of primary alcs. using methanol as a C1 building block. This borrowing hydrogen approach employs a well-defined bench-stable (cyclopentadienone)iron(0) carbonyl complex as precatalyst (5 mol %) and enables a diverse selection of substituted 2-arylethanols to undergo β-C(sp3)-methylation in good isolated yields (24 examples, 65% average yield). In addition to this study using 2-(2-Hydroxyethyl)pyridine, there are many other studies that have used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Application In Synthesis of 2-(2-Hydroxyethyl)pyridine) was used in this study.
2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. Pyridine is a relatively complex molecule and exhibits a number of different bands in IR spectra. Among others, the bands characterizing the ν8a and ν19b modes have been found to be sensitive to the coordination or protonation of the molecule. Note that the band that is diagnostic for the PyH+ ion at about 1545 cm− 1 (ν19b mode) does not overlap with any of the other bands.Application In Synthesis of 2-(2-Hydroxyethyl)pyridine