Allocolchicines-Synthesis with Electro-organic Key Transformations was written by Pollok, Dennis;Rausch, Florian U.;Beil, Sebastian B.;Franzmann, Peter;Waldvogel, Siegfried R.. And the article was included in Organic Letters in 2022.Application of 700-16-3 The following contents are mentioned in the article:
The naturally occurring colchicine and allocolchicines in the meadow saffron are potentially active ingredients for cancer therapy. A concise protocol for the sustainable synthesis of allocolchicines using up to two electro-organic key transformations is demonstrated. This straightforward synthesis of N-acetylcolchinol Me ether in a five-step protocol was adopted using protecting groups to enable access to N-acetylcolchinol and the phosphate derivative ZD6126. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Application of 700-16-3).
2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the è?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the è?bonds. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Application of 700-16-3