Premkumar, B. published the artcileFormulation and evaluation of Felodipine hollow microspheres, Application of 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, the main research area is blood pressure heart stroke felodipine hollow microsphere biocompatibility stability.
Felodipine is a calcium channel blocker which is used for the treatment of high blood pressure to prevent heart stroke. In the current research work hollow microspheres of Felodipine with better absorption in gastric pH was formulated by using various polymers. Drug polymer compatibility was characterized by FT-IR. Microspheres were prepared by emulsion solvent diffusion technique by using different polymers such as Et cellulose, carbopol 934, eudragit and sodium alginate at varying concentrations The formulations were evaluated for micromeritic properties, buoyancy, percentage yield, entrapment efficiency, in vitro studies and stability stuides. SEM photographs showed outer surface of microspheres was smooth and dense where as internal surface was porous which helped to prolong floating. Optimized F2 formulation exhibited higher release rate 95.55%. In vitro drug release studies showed controlled release of Felodipine for over 8h. Stability studies indicated the F2 formulation was stable with respect to its drug release.
European Journal of Biomedical and Pharmaceutical Sciences published new progress about Absorption. 72509-76-3 belongs to class pyridine-derivatives, name is 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C18H19Cl2NO4, Application of 3-Ethyl 5-methyl 4-(2,3-dichlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-3,5-dicarboxylate.