Prescott, B.; Stone, H. J. published an article in 1966, the title of the article was Means of increasing the tolerated dose of streptomycin in mice. Certain sulfonic acids.Reference of Pyridine-3-sulfonic acid And the article contains the following content:
With a 10 mg. dose of streptomycin, which was tolerated by only 7% of Swiss white and 12% of DBA mice, simultaneous administration of sulfanilic acid (25 mg.) or 6-thymolsulfonic acid (25 mg.) increased the tolerance to 93% of the Swiss white and 100% of the DBA mice tested. Sixty-seven percent of the Swiss white and 95% of the DBA mice survived 20 mg. streptomycin given concomitantly with the adjuvants. Pyridine-3-sulfonic acid (25 mg.) produced 90% survival in both strains of mice and dl-10-camphorsulfonic acid produced 83 and 100% survival in Swiss white and DBA mice, resp. Sixty percent of the mice tested survived 20 daily doses of 10 mg. streptomycin plus 25 mg. sulfanilic acid. The presence of free streptomycin in the blood of treated mice was demonstrated by the ability of serums to inhibit in vitro growth of Mycobacterium tuberculosis while the normal serum controls had no inhibitory action. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Reference of Pyridine-3-sulfonic acid
Pyridine-3-sulfonic acid(cas:636-73-7) belongs to pyridine-derivatives. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Reference of Pyridine-3-sulfonic acid