Prenyl Praxis: A Method for Direct Photocatalytic Defluoroprenylation was written by Priya, Sonal;Weaver, Jimmie D.. And the article was included in Journal of the American Chemical Society in 2018.Recommanded Product: 700-16-3 The following contents are mentioned in the article:
The prenyl fragment is the quintessential constituent of terpenoid natural products, a diverse family which contains numerous members with diverse biol. properties. In contrast, fluorinated and multifluorinated arenes make up an important class of anthropogenic mols. which are highly relevant to material, agricultural, and pharmaceutical industries. While allylation chem. is well developed, effective prenylation strategies have been less forthcoming. Herein, we describe the photocatalytic defluoroprenylation, a powerful method that provides access to “hybrid mols.” that possess both the functionality of a prenyl group and fluorinated arenes. This approach involves direct prenyl group transfer under very mild conditions, displays excellent functional group tolerance, and includes relatively short reaction times (<4 h), which is the fastest photocatalytic C-F functionalization developed to date. Addnl., the strategy can be extended to include allyl and geranyl (10 carbon fragment) transfers. Another prominent finding is a reagent-dependent switch in regioselectivity of the major product from para to ortho C-F functionalization. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Recommanded Product: 700-16-3).
2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule 伪-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Recommanded Product: 700-16-3