Category: pyridine-derivatives. Galli, U; Hysenlika, R; Meneghetti, F; Del Grosso, E; Pelliccia, S; Novellino, E; Giustiniano, M; Tron, GC in [Galli, Ubaldina; Hysenlika, Rejdia; Del Grosso, Erika; Tron, Gian Cesare] Univ Piemonte Orientale, Dipartimento Sci Farmaco, I-28100 Novara, Italy; [Meneghetti, Fiorella] Univ Milan, Dipartimento Sci Farmaceut, I-20133 Milan, Italy; [Pelliccia, Sveva; Novellino, Ettore; Giustiniano, Mariateresa] Univ Napoli Federico II, Dipartimento Farm, I-80131 Naples, Italy published Exploiting the Nucleophilicity of the Nitrogen Atom of Imidazoles: One-Pot Three-Component Synthesis of Imidazo-Pyrazines in 2019.0, Cited 38.0. The Name is 3-Pyridinecarboxaldehyde. Through research, I have a further understanding and discovery of 500-22-1.
A novel one-pot multicomponent reaction to synthesize substituted imidazopyrazines is described. In brief, 1H-(imidazol-5-yl)-N-substituted methanamines react with aldehydes and isocyanides in methanol at room temperature to give imidazopyrazine derivatives in excellent yields. The imidazole nitrogen atom was able to intercept the nascent nitrilium ion, channeling the reaction toward to the sole formation of imidazopyrazines, suppressing the competitive formation of other possible side products deriving from the reaction with the high-energy nitrilium ion. The number of examples and the variability of the nature of isocyanides, aldehydes, and amine components herein employed, witness the robustness of this novel methodology.
Category: pyridine-derivatives. Welcome to talk about 500-22-1, If you have any questions, you can contact Galli, U; Hysenlika, R; Meneghetti, F; Del Grosso, E; Pelliccia, S; Novellino, E; Giustiniano, M; Tron, GC or send Email.
Reference:
Pyridine – Wikipedia,
,Pyridine | C5H5N – PubChem