Pu, Chunlan published the artcileDesign, synthesis and biological evaluation of indole derivatives as Vif inhibitors, Application of 2-Bromopyridin-3-amine, the publication is Bioorganic & Medicinal Chemistry Letters (2017), 27(17), 4150-4155, database is CAplus and MEDLINE.
In this article, design, synthesis and biol. evaluation of indole derivatives as viral infectivity factor (Vif) inhibitors is reported. Fragment-based virtual screening (FBVS) was conducted and a series of fragments was obtained, among which, 5-(pyridin-2-yl)-1H-indole can form H-bonds with Tyr148 and Ile155 and based on this fragment other indole derivatives were synthesized. Through the immune-fluorescence staining and Western blot assays, 3-(1H-indol-5-yl)pyridin-6-amine (I) shows potent activity in inhibiting Vif-mediated A3G degradation Further docking experiment shows that compound I form H-bond interactions with residues His139, Tyr148 and Ile155. Therefore, I is a promising lead compound against Vif that can be used to treat AIDS.
Bioorganic & Medicinal Chemistry Letters published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Application of 2-Bromopyridin-3-amine.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem