In 2019,Journal of Bacteriology included an article by Qiu, Jiguo; Zhao, Lingling; Xu, Siqiong; Chen, Qing; Chen, Le; Liu, Bin; Hong, Qing; Lu, Zhenmei; He, Jian. Name: Picolinic acid. The article was titled 《Identification and characterization of a novel pic gene cluster responsible for picolinic acid degradation in Alcaligenes faecalis JQ135》. The information in the text is summarized as follows:
Picolinic acid (PA) is a natural toxic pyridine derivative Microorganisms can degrade and utilize PA for growth. However, the full catabolic pathway of PA and its physiol. and genetic foundation remain unknown. In this study, we identified a gene cluster, designated picRCEDFB4B3B2B1A1A2A3, responsible for the degradation of PA from Alcaligenes faecalis JQ135. Our results suggest that PA degradation pathway occurs as follows: PA was initially 6-hydroxylated to 6-hydroxypicolinic acid (6HPA) by PicA (a PA dehydrogenase). 6HPA was then 3-hydroxylated by PicB, a four-component 6HPA monooxygenase, to form 3,6-dihydroxypicolinic acid (3,6DHPA), which was then converted into 2,5-dihydroxypyridine (2,5DHP) by the decarboxylase PicC. 2,5DHP was further degraded to fumaric acid through PicD (2,5DHP 5,6-dioxygenase), PicE (N-formylmaleamic acid deformylase), PicF (maleamic acid amidohydrolase), and PicG (maleic acid isomerase). Homologous pic gene clusters with diverse organizations were found to be widely distributed in Alpha-, Beta-, and Gammaproteobacteria. Our findings provide new insights into the microbial catabolism of environmental toxic pyridine derivatives IMPORTANCE Picolinic acid is a common metabolite of L-tryptophan and some aromatic compounds and is an important intermediate in organic chem. synthesis. Although the microbial degradation/detoxification of picolinic acid has been studied for over 50 years, the underlying mol. mechanisms are still unknown. Here, we show that the pic gene cluster is responsible for the complete degradation of picolinic acid. The pic gene cluster was found to be widespread in other Alpha-, Beta-, and Gammaproteobacteria. These findings provide a new perspective for understanding the catabolic mechanisms of picolinic acid in bacteria. The results came from multiple reactions, including the reaction of Picolinic acid(cas: 98-98-6Name: Picolinic acid)
Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Name: Picolinic acid