Qiu, Shanguang;Chen, Yuxue;Song, Xinming;Liu, Li;Liu, Xi;Wu, Luyong published 《Potassium tert -Butoxide Promoted Synthesis of 4,5-Diaryl-2 H -1,2,3-triazoles from Tosylhydrazones and Nitriles》. The research results were published in《Synlett》 in 2021.Electric Literature of C6H4N2 The article conveys some information:
Intermol. cycloaddition of tosylhydrazones with nitriles was investigated. T-BuOK was shown to be an excellent base for increasing the effectiveness of the reaction in this protocol and homocoupling of the tosylhydrazones was significantly inhibited by using xylene as a solvent. Through this transformation, a variety of 4,5-diaryl-2 H-1,2,3-triazoles I [R1 = Ph, 4-MeC6H4, 4-ClC6H4, etc.; R2 = Ph, 3-BrC6H4, 2-thienyl, etc.] were prepared in good to excellent yields and with high purities. The process was azide-free and transition-metal-free.3-Cyanopyridine (cas: 100-54-9) were involved in the experimental procedure.
3-Cyanopyridine(cas: 100-54-9) is an antimicrobial agent that can be used in the treatment of infectious diseases.Electric Literature of C6H4N2 It has been shown to be effective against a variety of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae.