Radix, Sylvie published the artcileA Journey through Hemetsberger-Knittel, Leimgruber-Batcho and Bartoli Reactions: Access to Several Hydroxy 5- and 6-Azaindoles, Application In Synthesis of 71255-09-9, the main research area is azaindole preparation Hemetsberger Knittel Bartoli Leimgruber Batcho reaction.
The preparation of various 5- and 6-azaindoles, heterocyclic structures e.g., I that are frequently part of mols. in clin. development, and their monohydroxy analogs were described. Different strategies, relying on the de novo pyrrole ring formation, were investigated and, Hemetsberger-Knittel, Bartoli and Leimgruber-Batcho approaches, 4- and 7-monohydroxy 5- and 6-azaindoles e.g., I were obtained. The crucial introduction of the oxygen atom was carried out from halogen derivatives, using nucleophilic substitution reactions under basic conditions with or without a copper catalyst. Some preliminary oxidation reactions have shown that it was yet not possible to synthesize the azaquinone indole structure from monohydroxy azaindole, using mol. oxygen in the presence of salcomine as a catalyst.
Helvetica Chimica Acta published new progress about Bartoli reaction. 71255-09-9 belongs to class pyridine-derivatives, name is 2-Methoxynicotinaldehyde, and the molecular formula is C7H7NO2, Application In Synthesis of 71255-09-9.