《Minimum structural requirements for inhibitors of the zinc finger protein TRAF6》 was written by Radwan, Mohamed O.; Koga, Ryoko; Hida, Tomohiro; Ejima, Tomohiko; Kanemaru, Yosuke; Tateishi, Hiroshi; Okamoto, Yoshinari; Inoue, Jun-ichiro; Fujita, Mikako; Otsuka, Masami. Recommanded Product: 31106-82-8This research focused onzing finger TRAF6 inhibitor NF kappa B; Molecular docking; NF-κB; TRAF6; Zinc finger. The article conveys some information:
Zinc fingers have rarely been regarded as drug targets. On the contrary, the zinc-binding site of enzymes has often been considered a target of inhibitors. We previously developed a dithiol compound called SN-1(I) that binds to the zinc finger protein tumor necrosis factor receptor-associated factor 6 (TRAF6) and suppresses downstream nuclear factor-κB (NF-κB) signaling. To determine the minimal structure requirements of TRAF6 inhibitors based on I, NF-κB inhibitory activity and cytotoxicity of its derivatives including new compounds were examined SN-2(II), an oxidative type of prodrug of I with 2-nitrophenylthio groups via disulfide, has the min. structure for an inhibitor of TRAF6, as seen with cellular experiments The importance of two side chains with a thiol group was shown with mol. modeling. This study may lead to development of selective TRAF6 inhibitors in the near future. The results came from multiple reactions, including the reaction of 2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8Recommanded Product: 31106-82-8)
2-(Bromomethyl)pyridine hydrobromide(cas: 31106-82-8) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Recommanded Product: 31106-82-8