Ramirez-Palma, Lillian G.; Espinoza-Guillen, Adrian; Nieto-Camacho, Fabiola; Lopez-Guerra, Alexis E.; Gomez-Vidales, Virginia; Cortes-Guzman, Fernando; Ruiz-Azuara, Lena published their research in Molecules in 2021. The article was titled 《Intermediate Detection in the Casiopeina-Cysteine Interaction Ending in the Disulfide Bond Formation and Copper Reduction》.HPLC of Formula: 1134-35-6 The article contains the following contents:
A strategy to improve the cancer therapies involves agents that cause the depletion of the endogenous antioxidant glutathione (GSH), increasing its efflux out of cells and inducing apoptosis in tumoral cells due to the presence of reactive oxygen species. It has been shown that Casiopeina copper complexes caused a dramatic intracellular GSH drop, forming disulfide bonds and reducing CuII to CuI. Herein, through the determination of the [CuII]-SH bond before reduction, we present evidence of the adduct between cysteine and one Casiopeina as an intermediate in the cystine formation and as a model to understand the anticancer activity of copper complexes. Evidence of such an intermediate has never been presented before.4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6HPLC of Formula: 1134-35-6) was used in this study.
4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.HPLC of Formula: 1134-35-6 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.