Reactions of pyridin-2-ol, pyridin-3-ol, and pyridin-4-ol with pentafluoro- and pentachloropyridine was written by Ranjbar-Karimi, Reza;Davodian, Tayebeh;Mehrabi, Hossein. And the article was included in Chemistry of Heterocyclic Compounds in 2017.Electric Literature of C5F5N The following contents are mentioned in the article:
Reactions of pentafluoro- and pentachloropyridines with pyridin-2-ol, pyridin-3-ol and pyridin-4-ol are reported. Pyridin-4-ol yields product of attack at the nitrogen atom, while pyridin-3-ol reacts at the oxygen atom. Pyridin-2-ol reacts as an ambident nucleophile, providing a mixture of products I (X = F, Cl) and II arising from attack at both the oxygen and the nitrogen atoms. The structures of compounds were confirmed by IR spectroscopy, 1H, 13C and 19F NMR spectroscopy, as well as elemental anal. and X-ray crystallog. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Electric Literature of C5F5N).
2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule ä¼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Electric Literature of C5F5N