Survey reactivity of 5-substituted tetrazoles toward pentafluoropyridine was written by Ranjbar-Karimi, Reza;Poorfreidoni, Alireza. And the article was included in Journal of Fluorine Chemistry in 2019.Synthetic Route of C5F5N The following contents are mentioned in the article:
Reactivity of some 5-substituted tetrazoles with pentafluoropyridine under basic conditions in acetonitrile was investigated. The reaction of pentafluoropyridine with tetrazoles regioselectively occurred at the 4-position of pyridine ring by N2 in the tetrazole ring. Tetrazoles with Ph, 4-O2NC6H4, 4-CF3CONHC6H4, 4-ClC6H4CH2, EtO2CCH2 or 5-tetrazolyl-CH2 substituent at the position 5 gave the products I (R as listed above) containing unchanged tetrazole moiety. In contrast, tetrazole with substituents 3-(5-tetrazolyl)C6H4, 4-MeOC6H4 or 3-CF3CONHC6H4 at the position 5 gave hydrazide products, e.g., II (R = 4-MeOC6H4, 3-CF3CONHC6H4), via degradation of the tetrazole ring. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Synthetic Route of C5F5N).
2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Synthetic Route of C5F5N