Reams, Steve G. published the artcileEffect of chelating agents and respiratory inhibitors on regulation of the cadA gene in Escherichia coli, Related Products of pyridine-derivatives, the publication is Archives of Microbiology (1997), 167(4), 209-216, database is CAplus and MEDLINE.
The cadA gene that encodes Lys decarboxylase in E. coli is induced by low pH and during anaerobic growth by Lys. Operon fusions of cadA to lacZ was used to investigate the effects of aeration on cadA regulation. When an insertion mutation in osmZ (= hns) was introduced, a cadA-lacZ fusion was derepressed in the presence of air to approx. the same level as seen during anaerobic growth. The pH-dependent regulation of cadA was not affected by osmZ. Introduction of mutations in rpoS, fur, or fnr had no effect on cadA expression. Defects in arcB or arcA largely abolished expression of cadA during anaerobic growth. Nonetheless, strains defective in both arcB and osmZ showed the same high cadA-lac expression in air as seen in the single osmZ derivatives Blocking the respiratory chain with mutations or chem. inhibitors also caused derepression of a cadA-lacZ fusion in air, while agents affecting the proton gradient had no effect. Derepression of cadA in air was also mediated by several chelating agents, in particular by methoxyindole carboxylic acid. Addition of Fe2+ overcame this effect. Chelating agents also abolished the expression during aerobic growth of several genes known to be under arcAB control and which are normally repressed during anaerobic growth but induced in the presence of air. This implies that the effect of chelating agents on cadA expression is mediated via the arcAB regulatory system.
Archives of Microbiology published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Related Products of pyridine-derivatives.
Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem