Rechitskaya, E. D.; Kuratieva, N. V.; Lider, E. V.; Eremina, J. A.; Klyushova, L. S.; Eltsov, I. V.; Kostin, G. A. published the artcile< Tuning of cytotoxic activity by bio-mimetic ligands in ruthenium nitrosyl complexes>, Application In Synthesis of 93-60-7, the main research area is ruthenium nitrosyl isonicotinate nicotinate complex preparation cytotoxic activity; crystal structure ruthenium nitrosyl isonicotinate nicotinate complex.
Three novel ruthenium nitrosyl complexes [Ru(NO)Cl3(InicMe)2] (1b), [RuNOCl3(NicEt)2] (1c) and [RuNOCl3(NicMe)2] (1d) (InicMe = Me isonicotinate, NicEt = Et nicotinate, NicMe = = Me nicotinate)were prepared and crystal structure of the complexes were determined by single crystal XRD anal. In all complexes, the organic ligands are coordinated by a pyridine nitrogen atom and located in trans-position each to other and in cis-position to NO group. In the crystal package of all compounds stacking interactions of two types were determined: πarene-πarene and πCOO-πarene stacking. Finally, cytotoxicity of the compounds was tested on Hep2 and HepG2 cell lines. In the set of similar compounds mer-[RuNO(L)2Cl3] (L = Py, γ-Pic, β-Pic, Inic-Alk, Nic-Alk), complexes with iso-nicotinic acid esters are the most toxic, while nicotinic acid derivatives are less toxic and compared with pyridine complex.
Journal of Molecular Structure published new progress about Antitumor agents. 93-60-7 belongs to class pyridine-derivatives, and the molecular formula is C7H7NO2, Application In Synthesis of 93-60-7.