Reina, Miguel; Hernandez-Ayala, Luis Felipe; Bravo-Gomez, Maria Elena; Gomez, Virginia; Ruiz-Azuara, Lena published their research in Inorganica Chimica Acta in 2021. The article was titled 《Second generation of Casiopeinas: A joint experimental and theoretical study》.Recommanded Product: 1134-35-6 The article contains the following contents:
Herein, we present the synthesis, characterization, DFT calculations and in vitro evaluation of antiproliferative activity against HeLa and MCF-7 cancer tumor cell lines of three novel second generation Casiopeinas complexes. These compounds are characterized by the substitution of the usual neg. charged secondary ligand with a neutral bidentate ligand (2AMB = 2-aminomethylbenzimidazole), in order to improve both hydrophilicity and antiproliferative activity. Geometry for the compounds in this study assumes that complexes present a five-coordination number with a square pyramidal geometry, in which two bidentate ligands are in the plane and a nitrate anion is bonded in the axial position. Among analyzed complexes, only [Cu(4,7-dimethyl-1,10-phenanthroline)(2AMB)(NO3)]NO3 (1) is shown to be more effective than the referenced cisplatin drug, against both HeLa and MCF-7 tumor cell lines. Finally, for studied compounds, structure-activity relationships are strongly determined by either the calculated molar volume (V) or the redox potential (E1/2) of CuII/CuI of the complexes. These results aim to encourage further joint exptl. theor. studies, not only to describe biol. activity, but also to predict it. The experimental part of the paper was very detailed, including the reaction process of 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Recommanded Product: 1134-35-6)
4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Recommanded Product: 1134-35-6 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.