Pyridine has a conjugated system of six π electrons that are delocalized over the ring. 766-11-0, formula is C5H3BrFN, Name is 5-Bromo-2-fluoropyridine. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Category: pyridine-derivatives.
Remeur, Camille;Kelly, Christopher B.;Patel, Niki R.;Molander, Gary A. research published 《 Aminomethylation of Aryl Halides Using α-Silylamines Enabled by Ni/Photoredox Dual Catalysis》, the research content is summarized as follows. In the presence of the ruthenium photocatalyst [Ru(bipy)3](PF6–)2 and the nickel catalyst [Ni(dtbpy)(OH2)4]Cl2 (dtbpy = 4,4′-di-tert-butyl-2,2′-bipyridine), aryl bromides and iodides such as 4-bromobenzonitrile underwent chemoselective aminomethylation reactions with aminomethylsilanes such as 1-(dimethylphenylsilylmethyl)piperidine in DMF under irradiation with blue LED for 24-36 h at ambient temperature to yield benzylic amines such as 4-(1-piperidinylmethyl)benzonitrile in 41-70% yields. The low oxidation potential of the silylmethyl amines enabled facile single electron transfer (SET) oxidation of the amine followed by rapid desilylation; the resultant α-amino radicals were competent to undergo nickel-mediated cross-coupling with aryl bromides and iodides.
766-11-0, 5-Bromo-2-fluoropyridine is a useful research compound. Its molecular formula is C5H3BrFN and its molecular weight is 175.99 g/mol. The purity is usually 95%.
5-Bromo-2-fluoropyridine is a boronic acid that has been shown to react with iodides and form 5-bromo-2-fluoroiodobenzene. The reaction of 5-bromo-2-fluoropyridine with benzene gives the same product as the reaction with 1,3,5-trioxane. The UV absorption of 5-bromo-2-fluoropyridine is found at 230 nm and 260 nm. It also has an absorption band in the infrared region at 1625 cm−1. Vibrational progressions have been observed for this molecule, which are due to dipole moments and electron density distributions in the molecule.
5-bromo-2-fluoropyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. , Category: pyridine-derivatives