Ren, Hang published the artcileVersatile synthesis and biological evaluation of novel 3′-fluorinated purine nucleosides, Category: pyridine-derivatives, the main research area is Suzuki Stille coupling nucleoside fluororibose human aminopurine preparation antitumor; 3’-fluororibonucleoside; 6-substituted purine; anticancer; purine nucleoside; synthesis.
A unified synthetic strategy accessing novel 3′-fluorinated purine nucleoside derivatives and their biol. evaluation were achieved. Novel 3′-fluorinated analogs were constructed from a common 3′-deoxy-3′-fluororibofuranose intermediate. Employing Suzuki and Stille cross-coupling reactions, fifteen 3′-fluororibose purine nucleosides, e.g. I, and eight 3′-fluororibose 2-chloro/2-aminopurine nucleosidese, e.g. II, with various substituents at position 6 of the purine ring were efficiently synthesized. Furthermore, 3′-fluorine analogs of natural products nebularine and 6-methylpurine riboside were constructed via our convergent synthetic strategy. Synthesized nucleosides were tested against HT116 (colon cancer) and 143B (osteosarcoma cancer) tumor cell lines. We have demonstrated 3′-fluorine purine nucleoside analogs display potent tumor cell growth inhibition activity at sub- or low micromolar concentration
Beilstein Journal of Organic Chemistry published new progress about Antitumor agents. 917471-30-8 belongs to class pyridine-derivatives, name is (5-(Prop-1-yn-1-yl)pyridin-3-yl)boronic acid, and the molecular formula is C8H8BNO2, Category: pyridine-derivatives.